Adolescent Tumours – ESGO Gynae-Oncology Guidelines

ESGO-SIOPe Guidelines for Non-Epithelial Ovarian Cancers in Adolescents and Young Adults


ESGO in cooperation with the European Society for Paediatric Oncology (SIOPe) has released the recommendations for the treatment of adolescents and young adults with non-epithelial ovarian tumours, which have been published in July 2020 in The Lancet Oncology.

These first ever clinically relevant and evidence-based guidelines were developed in response to a growing need to improve the quality of care for adolescents and young adults aged 15 to 25 years with  these rare tumours, including malignant ovarian germ cell tumours, sex cord-stromal tumours, and small cell carcinoma of the ovary of hypercalcaemic type.

The developmental process of these guidelines is based on a systematic literature review and critical appraisal process involving an international multidisciplinary developmental group consisting of experts from relevant disciplines (paediatric oncology, paediatric surgery, medical oncology, pathology, psycho-oncology, gynaecological oncology, and reproductive endocrinology).

Given the specific and often complex issues involved in treating this group of patients, fertility sparing surgery and decrease of acute and long-term toxicities from treatment were important criteria for guidelines definition.

Prior to publication, the guidelines were reviewed by 54 independent international practitioners in cancer care delivery.

Interested to find out more?

  • You can download a free copy of the Pocket Guidelines edition

ESGO-SIOPe Non-Epithelial Ovarian Cancers in Adolescents and Young Adults

Guidelines International Experts Panel




Cristiana Sessa Medical oncologist (chair) Oncology Institute of Southern Switzerland, Bellinzona (Switzerland)
Gabriele Calaminus Paediatric oncologist (chair) University Clinic Bonn, Bonn (Germany)
François Planchamp Methodologist Institut Bergonié, Bordeaux (France)
Katja Baust Psychooncologist Universitätsklinikum, Bonn (Germany)
Elena Ioana Braicu Gynaecologic oncologist Charité-Universitätsmedizin Berlin, Berlin (Germany)
Nicole Concin Gynaecologic oncologist Medical University of Innsbruck, Innsbruck (Austria)
Jan Godzinski Paediatric surgeon T. Marciniak Lower Silesian Specialized Hospital, Wroclaw (Poland)
W. Glenn McCluggage Pathologist Belfast Health & Social Care Trust, Belfast (United Kingdom)
Philippe Morice Gynaecologic oncologist Institut Gustave Roussy, Villejuif (France)
Daniel Orbach Paediatric oncologist Institut Curie, Paris (France)
Patricia Pautier Medical oncologist Institut Gustave Roussy, Villejuif (France)
Fedro Pecatori Reproductive endocrinologist European Institute of Oncology, Milan (Italy)
Dominik T. Schneider Paediatric oncologist Klinikum Dortmund, Dortmund (Germany)

External Reviewers

ESGO would also like to thank external reviewers who have taken the time to provide their feedback on the document elaborated in the framework of the ESGO-SIOPe Guidelines for the Management of Adolescents and Young Adults with Non-epithelial Ovarian cancers Project.

List of reviewers ESGO-SIOPe Ovarian Cancers in Adolescents GL


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