Algorithms – ESGO Gynae-Oncology Guidelines

ESGO-GCIG Rare Cancers Guidelines Project


The European Society of Gynaecological Oncology (ESGO) and the Gynecologic Cancer Intergroup (GCIG) jointly developed clinically relevant and evidence-based algorithms for rare tumours, based on the previously elaborated initial project that was published in the Int J Gyn Cancer in 2014.

The first guidelines draft was presented at the GCIG meeting in Chicago in June 2019 for comments and revision. After this meeting, both GCIG and ESGO societies circulated the different guidelines for definitive validation.

The new guidelines covering the initial 10 cancer types were officially presented for the first time at the ESGO 21st European Congress on Gynaecological Oncology in November 2019 in Athens, Greece.

The initial 10 tumour types include: Leiomyosarcomas, Carcinosarcoma, Sex Cord Tumours, Germ cell tumours, Cancerized teratoma, trophoblastic disease, ovarian clear cell carcinoma, ovarian mucinous carcinoma, ovarian low-grade serous carcinoma and small cell ovarian carcinoma hypercalcaemic.

View the working groups.



The Gynecologic Cancer Intergroup (GCIG)

The GCIG is a collaboration of 29 international cooperative clinical trials groups from various countries who are committed to conduct high-quality randomized phase III trials among women with gynecologic cancers.

Founded in 1993 and formalized in 1997, GCIG has developed from a small network of ovarian cancer researchers to a large international forum addressing multiple issues related to research in gynecologic cancers. Member groups of the GCIG have collaboratively conducted pivotal clinical trials in cancers of the ovary, endometrium, and cervix.

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ESGO-GCIG Rare Cancers Working Groups


ESGO would like to express its sincere gratitude to the international experts’ panel and reviewers, who devoted their time and effort to the ESGO-GCIG Rare Cancers guidelines and algorithms project of the first ten tumour types.


Working Groups

For each of these 10 tumour types, two chairs from different national cooperative groups were invited to co-ordinate the activity. Each of the 10 working groups included members from the GCIG groups a pathologist and a MethodologistFrançois Planchamp, France.

The release of the Rare Cancers Algorithms Mobile App version in late 2020 will include the following tumour types prepared by the working groups below.


Low Grade Serous Carcinoma

GCIG Group Name Country
GOG-F David Gershenson (coordinator) United States of America
SGCTG Charlie Gourley (co-coordinator) United Kingdom
COGI Ann Folkins United States of America
ISGO Ora Rosengarten Israel
GOTIC Masanori Yasuda Japan
NOGGO Jalid Sehouli Germany
AGO-AUST Thorsten Fischer Austria
Br-GOG Rodrigo Fernandes Brazil
CTI (ICORG) Donal Brennan Republic of Ireland
CEEGOG David Cibula Czech Republic
KGOG Miseon Kim Korea
GINECO Fabrice Lecuru France
AGO Pauline Wimberger Germany
NCI US Elise Kohn United States of America
SGCTG Patricia Roxburgh United Kingdom
DGOG Christianne Lok The Netherlands

Ciaran O’Riain (CTI) Republic of Ireland


Ovarian Clear Cell Carcinoma

GCIG Group Name Country
GEICO Antonio Gonzales (coordinator) Spain
GOTIC Keiichi Fujiwara (co-coordinator) Japan
NOGGO Jacek Grabowski Germany
CTI (ICORG) Paula Calvert Republic of Ireland
MITO Sandro Pignata Italy
NCI US Jung-min Lee United States of America
AGO-AUST Christian Schauer Austria
CEEGOG Lukas Rob Czech Republic
AGO Ahmed El-Balat Germany
GINECO Elsa Kalbacher France
Br-GOG Mariana de Paiva Batista Brazil
GOTIC Masashi Takano Japan
G-GOC Rob Coleman United States of America
KGOG Se Ik Kim Korea
COGI Ann Folkins United States of America
SGCTG Ros Glasspool United Kingdom
DGOG Ingrid Boere The Netherlands
KGOG Chong-Woo Yoo Korea


Ovarian Sex-Cord Stromal Tumour

Group Name Country
GINECO Isabelle Ray-Coquard (coordinator) France
AGO Philip Harter (co-coordinator) Germany
DGOG Anneke. M Westermann The Netherlands
NOGGO Sara Alavi Germany
AGO Gunter Emons Germany
MITO Gennaro Cormio Italy
G-GOG Lois Ramondetta United States of America
Br-GOG Giovanni Miglino Brazil
SGCTG Nick Reed United Kingdom
KGOG Byoung Soo Kwon Korea
GOTIC Hitoshi Tsuda Japan
GINECO Florence Joly France
COGI Amer Karam United States of America
NOGGO Wolfgang Schmitt Germany
A-AGO Alain Zeimet Austria


Ovarian Germ Cell Tumour

GCIG Group Name Country
MaNGO Nicoletta Colombo (coordinator) Italy
NSGO Olesya Solheim (co-coordinator) Sweden
AGO Annette Hasenburg Germany
CEEGOG Helena Robova Czech Republic
MITO Ugo de Giorgi Italy
Br-GOG Maria Del Pilar Estevez Diz Brazil
CTI (ICORG) Dearbhaile O'Donnell Ireland
COGI Jonathan Berek United States of Amercia
AGO-AUST Christian Marth Austria
GINECO Frederic Selle France
KGOG Seung-Hyuk shim Korea
G-GOC Aaron Shafer United States of America
SGCTG Ros Glasspool United Kingdom
DGOG Ingrid Boere The Netherlands
NOGGO Ioana Braicu Germany

Sarit Aviel-Ronen (ISGO) Israel


Ovarian Mucinous Carcinoma

Group Name Country
NCRI Jonathan Ledermann (coordinator) United Kingdom
GOG-F Jubilee Brown (co-coordinator) United States of America
DGOG Christianne Lok The Netherlands
ISGO Dalia Tsoref Israel
AGO-AUST Edgar Petru Austria
G-GOC Michael Frumovitz United States of America
KGOG Jung-Yun Lee Korea
COGI Oliver Dorigo United States of America
NCI US Elise Kohn United States of America
NOGGO Pauline Wimberger Germany
Br-GOG Francisco José C. Reis Brazil
GINECO Sebastien Gouy France
MITO Giorgio Valabrega Italy
SGCTG Charlie Gourley United Kingdom
AGO Frederik Marmé Germany

Mojgan Devouassoux (GINECO) France

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